Amazing Spider-Man  (1962)

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Marvel Aug 1990

Amazing Spider-Man #337

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1st full team appearance of the Sinister Six II: Doctor Octopus, Electro, Mysterio, Sandman, Hobgoblin, Vulture
This is the second Sinister Six roster of villains
The Sinister Six introduced in The Amazing Spider-Man Annual #1 only appeared together once, therefore this issue would be the second full appearance ever of a Sinister Six team
Marvel Oct 1990

Amazing Spider-Man #340

Mark Jewelers
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1st team appearance of the Femme Fatales: Knockout (1st), Mindblast (1st), Whiplash, Bloodlust
Marvel Feb 1991

Amazing Spider-Man #344

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1st appearance of Cletus Kasady, later becomes Carnage
1st full appearance of Cardiac, a doctor who vowed to find a cure for the ailment that caused the death of his brother
Marvel Feb 1991

Amazing Spider-Man #344

Mark Jewelers
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1st appearance of Cletus Kasady, later becomes Carnage
1st full appearance of Cardiac, a doctor who vowed to find a cure for the ailment that caused the death of his brother
Marvel Mar 1991

Amazing Spider-Man #345

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Cletus Kasady becomes infected by the Venom symbiote, later becomes Carnage
[March 2026 - a glimpse of Spider-Man battling Boomerang in the Brand New Day trailer was inspired by this cover - tap cover and swipe to view screenshot]

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