1st appearance of Nova, Sam Alexander
1st appearance of Kaine as the Scarlet Spider
1st appearance of Dragonfire and Coldmoon
Death of Terrax the Tamer
1st team appearance of X-Terminated: Horror Show, Fiend, Deadeye, Prophet, Goodnight
Debut of Doctor Strange from an alternate Earth with new costume design
[March 2022 - Deadline reports a Nova project is in development]